Aspartame: A review of genotoxicity data

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Autor(en) : Kirkland D, Gatehouse D
Name der Veröffentlichung : Food Chem Toxicol. 2015 Oct; 84: 161-8. doi: 10.1016/j.fct.2015.08.021. Epub 2015 Aug 28
Erscheinungsjahr : 2015

Abstract

Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to a number of carcinogenicity studies. The in vitro and in vivo genotoxicity data available on aspartame are considered sufficient for a thorough evaluation. There is no evidence of induction of gene mutations in a series of bacterial mutation tests. There is some evidence of induction of chromosomal damage in vitro, but this may be an indirect consequence of cytotoxicity. The weight of evidence from in vivo bone marrow micronucleus, chromosomal aberration and Comet assays is that aspartame is not genotoxic in somatic cells in vivo. The results of germ cell assays are difficult to evaluate considering limited data available and deviations from standard protocols. The available data therefore support the conclusions of the European Food Safety Authority (EFSA) that aspartame is non-genotoxic.

Summary

This paper by Kirkland and Gatehouse reviewed data from multiple in vitro and in vivo genotoxicity studies with aspartame, concluding that available data support the conclusions of the European Food Safety Authority (EFSA) that aspartame does not show any genotoxic potential (EFSA, 2013).

The authors conclude that there is no evidence of induction of gene mutations in a series of bacterial mutation tests and that reported increases in chromosomal damage in vitro have not been confirmed in vivo. In all, the in vitro and in vivo genotoxicity data available on aspartame are considered sufficient for a thorough evaluation and support that aspartame is non-genotoxic.

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