Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study
Abstract Background: The food industry uses artificial sweeteners in a wide range of foods and beverages as alternatives to added sugars, for which deleterious effects on several chronic diseases are now well established. The safety of these food additives is debated, with conflicting findings regarding their role in the aetiology of various diseases. In particular, their […]
Health effects of the use of non-sugar sweeteners: a systematic review and meta-analysis
Abstract – Summary The current systematic review and meta-analysis by the World Health Organization (WHO) suggests that the use of low/no calorie sweeteners leads to modest yet significant reductions in body weight in adults without any significant impact on cardiometabolic risk, as assessed in randomised controlled trials (RCTs); in contrast, observational studies report a positive […]
Re-evaluation of thaumatin (E 957) as food additive
Abstract The present opinion deals with the re-evaluation of thaumatin (E 957) when used as a food additive. Thaumatin is a natural plant protein, consisting of thaumatin I and thaumatin II proteins together with minor amounts of plant constituents, obtained by acidic aqueous extraction of the arils of the fruit of Thaumatococcus daniellii plant. The […]
Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies
Abstract BACKGROUND Adverse associations of low- and no-calorie sweetened beverages (LNCSB) with cardiometabolic outcomes in observational studies may be explained by reverse causality and residual confounding. PURPOSE To address these limitations we used change analyses of repeated measures of intake and substitution analyses to synthesize the association of LNCSB with cardiometabolic outcomes. DATA SOURCES MEDLINE, […]
Dietary exposure to artificial sweeteners and associated factors in the Portuguese population
Abstract This study aimed to evaluate the risk of the Portuguese population’s exposure to six non-nutritive intense sweeteners (NNIS) and their main associated factors. A tiered approach was used to estimate the usual exposure to the NNIS obtained from two 1-day food diaries among children and two 24-hour recalls among adults in the Portuguese national […]
Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar Sweetened Beverages With Body Weight and Cardiometabolic Risk. A Systematic Review and Meta-analysis
Abstract IMPORTANCE There are concerns that low- and no-calorie sweetened beverages (LNCSBs) do not have established benefits, with major dietary guidelines recommending the use of water and not LNCSBs to replace sugar-sweetened beverages (SSBs). Whether LNCSB as a substitute can yield similar improvements in cardiometabolic risk factors vs water in their intended substitution for SSBs […]
The effects of artificial- and stevia-based sweeteners on lipid profile in adults: a GRADE assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials
Abstract: It has been posited that Non-nutritive sweeteners (NNS) intake may affect lipid profile. However, its proven effects on lipid profile are unclear, as clinical studies on this topic have produced inconsistent results. To fill this gap in knowledge, this systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of […]
Low- and no-calorie sweetener intakes in the Brazilian population estimated using added sugar substitution modelling
Abstract This research examined the intakes of six low- and no-calorie sweeteners (LNCS) (acesulfame-K, aspartame, cyclamate, saccharin, steviol glycosides, and sucralose) by the Brazilian population using an added sugar substitution approach. Detailed exposure modelling requires the use of proprietary concentration data, which can be difficult to obtain. Two exposure models were conducted using nationally representative […]
Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials.
Abstract: The consumption of sugar-free foods is growing because of their low-calorie content and the health concerns about products with high sugar content. Sweeteners that are frequently several hundred thousand times sweeter than sucrose are being consumed as sugar substitutes. Although nonnutritive sweeteners (NNSs) are considered safe and well tolerated, their effects on glucose intolerance, […]
Evaluación exposición dietaria crónica a edulcorantes en alimentos consumidos por la población chilena
Abstract: La Agencia Chilena para la Inocuidad y Calidad Alimentaria (ACHIPIA), llevó a cabo una evaluación de exposición dietaria crónica, solicitada por el Ministerio de Salud (MINSAL). En ella se evaluó la ingesta de cuatro edulcorantes no nutritivos autorizados en el Reglamento Sanitario de los Alimentos (acesulfamo potásico, aspartamo, sucralosa y glicósidos de esteviol) consumidos […]