Non-caloric sweeteners in women of reproductive age – A consensus document
Abstract Non-nutritive sweeteners (NNS) are food additives that have been used as a possible tool to reduce energy and sugar intake. There is a scientific debate around the real benefits of their use. NNS are substances widely evaluated in the scientific literature. Their safety is reviewed by international regulatory health agencies. Health professionals and consumers […]
Expert consensus on low-calorie sweeteners: facts, research gaps and suggested actions
Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to the science and policy of LCS: (1) weight management and glucose control; (2) consumption, safety and perception; (3) nutrition policy. The aims were to identify the reliable facts on LCS, […]
Non-caloric sweeteners and kidney disease: Evidence analysis
Abstract Non-caloric sweeteners (NCS) are food additives with sweet taste used as a tool to substitute sugar consumption and reduce energy intake. There is scientific controversy surrounding possible risks of its use, which is under continuous discussion in the academic and also in the public scenario. NCS are substances widely evaluated in the scientific literature. […]
Lack of potential carcinogenicity for sucralose – Systematic evaluation and integration of mechanistic data into the totality of the evidence
Abstract Sucralose is widely used as a sugar substitute. Many studies and authoritative reviews have concluded that sucralose is non-carcinogenic, based primarily on animal cancer bioassays and genotoxicity data. To add to the body of knowledge on the potential carcinogenicity of sucralose, a systematic assessment of mechanistic data was conducted. This entailed using a framework […]
Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence
Abstract Despite repeated confirmation of aspartame safety in a variety of foods and beverages, there continues to be interest in researching the potential carcinogenic risk associated with its consumption. The objective of this evaluation was to conduct a systematic assessment of available mechanistic data using a framework for quantitatively integrating the key characteristics of carcinogens […]
Revisión de la evidencia científica y opinión técnica sobre el consumo de edulcorantes no calóricos en enfermedades gastrointestinales [Review of the scientific evidence and technical opinion on noncaloric sweetener consumption in gastrointestinal diseases]
Abstract The present review of noncaloric sweeteners (NCSs) by the Asociación Mexicana de Gastroenterología was carried out to analyze and answer some of the most frequent questions and concerns about NCS consumption in patients with gastrointestinal disorders, through a thorough review of the medical literature. A group of gastroenterologists and experts on nutrition, toxicology, microbiology, and endocrinology […]
Potential consumer exposures to low/no calorie sweeteners: a refined assessment based upon market intelligence on use frequency, and consideration of niche applications
Abstract Data on current use levels of E950 acesulfame K, E952 cyclamic acid and its Na and Ca salts, E954 saccharin and its Na, K and Ca salts, E955 sucralose and E957 thaumatin, have been collected by the European food and drink industry in response to an EFSA call for data in support of its […]
Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria
Abstract Given the widespread use of the low-calorie sweetener aspartame over the last 30 years, the current work was undertaken to evaluate aspartame epidemiology studies looking at cancer endpoints against quality appraisal criteria. The quality appraisal tool used was from the National Heart, Lung and Blood Institute (NHLBI) of the National Institute of Health. Studies […]
Estimation of exposures to non-nutritive sweeteners from consumption of tabletop sweetener products: a review
Abstract Reliable estimation of intake of non-nutritive sweeteners (NNS) from tabletop sweetener products (TTS) is complex. Some TTS contain more than one type of NNS and more importantly, there can be considerable formula variation between different types of TTS products; that is liquid, powder and tablet products. A survey of use levels (mg NNS/kg TTS […]
Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota
Abstract Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes […]