Systematic review and evaluation of aspartame carcinogenicity bioassays using quality criteria
Abstract The current review assessed cancer studies of aspartame based on a quality appraisal using the Klimisch grading system. Nine studies having complete histopathology were included: three 2-year studies by Searle; three transgenic mice studies by the NTP; three lifetime studies by the Ramazzini Institute. A tenth study limited to brain tumors was not rated. […]
Dietary intakes of six intense sweeteners by Irish adults
Abstract This research investigated the intakes of six intense sweeteners; acesulfame-K (E950), aspartame (E951), cyclamate (E952), saccharin (E954), sucralose (E955) and steviol glycosides (E960) in the diets of Irish adults, using data from the National Adult Nutrition Survey (NANS). A food label survey which included products currently available on the Irish market supplemented the analysis. […]
Aspartame: A review of genotoxicity data
Abstract Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to […]
Non-nutritive Sweeteners for Diabetes Mellitus
Abstract Background: Products sweetened with non-nutritive sweeteners (NNS) are widely available. Many people with type 1 or type 2 diabetes use NNS as a replacement for nutritive sweeteners to control their carbohydrate and energy intake. Health outcomes associated with NNS use in diabetes are unknown. Objectives: To assess the effects of non-nutritive sweeteners in people […]
Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report
Summary This Consensus Report of the American Diabetes Association (ADA) is intended to provide clinical professionals with evidence-based guidance about individualizing nutrition therapy for adults with diabetes or prediabetes. Nutrition counselling that works toward improving or maintaining glycaemic targets, achieving weight management goals, and improving cardiovascular risk factors (e.g., blood pressure, lipids, etc.) within individualized […]
The use of low or no calorie sweeteners. Position Statement (Updated December 2018)
Summary The updated Diabetes UK Position Statement on low calorie sweeteners reviews current evidence and provides a set of recommendations about their use. The main conclusion is that: “LNCS [low or no calorie sweeteners] are shown to be safe and they can be used as part of a strategy for adults and children in the […]
Consumption of a Carbonated Beverage with High-Intensity Sweeteners Has No Effect on Insulin Sensitivity and Secretion in Nondiabetic Adults
Abstract Background: The effects of the regular intake of beverages containing high-intensity sweeteners on insulin sensitivity in healthy individuals remain controversial. Objective: This trial compared the effects of the consumption of a carbonated beverage containing aspartame and acesulfame K (high-intensity sweeteners beverage—HISB) with those of an unsweetened, no-calorie carbonated beverage (UB) on insulin sensitivity and secretion in […]
Consumption of a Carbonated Beverage with High-Intensity Sweeteners Has No Effect on Insulin Sensitivity and Secretion in Nondiabetic Adults
Abstract Background: The effects of the regular intake of beverages containing high-intensity sweeteners on insulin sensitivity in healthy individuals remain controversial. Objective: This trial compared the effects of the consumption of a carbonated beverage containing aspartame and acesulfame K (high-intensity sweeteners beverage—HISB) with those of an unsweetened, no-calorie carbonated beverage (UB) on insulin sensitivity and secretion in […]
Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials
Abstract Background/ Objectives: Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. Subjects/ Methods: PubMed and Web of Science databases were searched. Two authors screened the titles and […]
Aspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled Trial
Abstract Background: Low-calorie sweeteners are often used to moderate energy intake and postprandial glycemia, but some evidence indicates that they may exacerbate these aims. Objective: The trial’s primary aim was to assess the effect of daily aspartame ingestion for 12 wk on glycemia. Effects on appetite and body weight were secondary aims. Methods: One hundred lean [body mass […]