Scientific library

The Science Library is a useful resource, which is easy to navigate, and provides abstracts and brief summaries with the main findings of key scientific studies published in peer-reviewed journals, on low/no calorie sweeteners’ safety, benefits and role in the diet.

Covering a wide range of topics such as the role of low/no calorie sweeteners in weight management and obesity, their use in diabetes management, their impact on oral health, their safety, the role of sweet taste overall, scientists and health professionals can easily find here all the latest studies of the scientific literature.

Author(s): Farhat G, Dewison F, Stevenson L.
Publication name: Nutrients 2021; 13(2): 444. doi:10.3390/nu13020444
Publication year: 2021

Abstract Non-nutritive sweeteners (NNS) are popular sugar substitutes that can help in weight and diabetes management, but concerns regarding their use have been raised by…

Author(s): Laviada-Molina H, Espinosa-Marrón A, Martinez-Portilla RJ, Molina-Segui F.
Publication name: Diabet Med. 2021 Jan 11:e14520. doi: 10.1111/dme.14520. Online ahead of print.
Publication year: 2021

Abstract There is a current debate on the effects of artificial sweeteners on health-related outcomes among different populations. Even when meta-analytic evidence has revealed that…

Author(s): Gallagher AM, Ashwell M, Halford JCG, Hardman CA, Maloney NG and Raben A.
Publication name: Journal on Nutritional Science 2021; 10:E7. doi:10.1017/jns.2020.59
Publication year: 2021

Abstract Overconsumption of free sugars, particularly from sugar-sweetened beverages (SSB), has potential negative health impacts. Implementation of a range of public health strategies is needed…

Author(s): Serrano J, Smith KR, Crouch AL, Sharma V, Yi F, Vargova V, LaMoia TE, Dupont LM, Serna V, Tang F, Gomes-Dias L, Blakeslee JJ, Hatzakis E, Peterson SN, Anderson M, Pratley RE, Kyriazis GA.
Publication name: Microbiome 2021;9:11. doi: 10.1186/s40168-020-00976-w
Publication year: 2021

Abstract Background: Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, some interventional studies in…

Author(s): Lee HY, Jack M, Poon T, Noori D, Venditti C, Hamamji S, Musa-Veloso K.
Publication name: Advances in Nutrition 2021 Jan 13;nmaa157. doi:10.1093/advances/nmaa157
Publication year: 2021

Abstract Effects of isocaloric (sweetness differences but constant calories) preloads and isosweet (caloric differences but constant sweetness) preloads, as well as preloads that were neither…

Author(s): Laviada-Molina H, Molina-Segui F, Pérez-Gaxiola G, Cuello-García C, Arjona-Villicaña R, Espinosa-Marrón A, Martinez-Portilla RJ.
Publication name: Obesity Reviews 2020; 1-13. https://doi.org/10.1111/obr.13020
Publication year: 2020

Abstract There is an ongoing debate about the possible influences of nonnutritive sweeteners (NNS) on body weight. We conducted a systematic review and meta?analysis of…

Author(s): Ahmad SY, Friel JK, MacKay DS.
Publication name: Nutrients 2020; 12(11): 3408. Doi:10.3390/nu12113408
Publication year: 2020

Abstract Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine…

Author(s): Rogers PJ, Appleton KM.
Publication name: Int J Obes (2020). https://doi.org/10.1038/s41366-020-00704-2
Publication year: 2020

Abstract Previous meta-analyses of intervention studies have come to different conclusions about effects of consumption of low-calorie sweeteners (LCS) on body weight. The present review…

Author(s): Barraj L, Scrafford C, Bi X and Tran N.
Publication name: Food Additives & Contaminants: Part A, 2020. doi: 10.1080/19440049.2020.1846083
Publication year: 2020

Abstract Estimated intake of six low and no-calorie sweeteners (LNCS) (acesulfame potassium, aspartame, cyclamate, saccharin, steviol glycosides and sucralose) from processed foods and beverages, as…

Author(s): Ashwell M, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, López-García R, Magnuson B, Mellor D, Rogers P, Rowland I, Russell W, Sievenpiper J, La Vecchia C
Publication name: Nutr Res Rev. 2020;33(1):145-154. doi: 10.1017/S0954422419000283. [Epub ahead of print]
Publication year: 2020

Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to…

Author(s): Uriza RB, Méndez JAA, Cavagnari B, González CC, Tellez RC, Brambila JC, Marrón AE, Plascencia JL, López Alarcón MG, López García R, Maldonado Alvarado JdD, Molina Seguí F, Neri Ruz ES, Peralta Sánchez AE, Escamilla MTSR, Tena Alavez G, Riobó Serván P
Publication name: Nutr Hosp. 2020 Jan 21. doi: 10.20960/nh.02870. [Epub ahead of print] (article in Spanish)
Publication year: 2020

Abstract Non-nutritive sweeteners (NNS) are food additives that have been used as a possible tool to reduce energy and sugar intake. There is a scientific…

Author(s): O’Connor D, Pang M, Castelnuovo G, Finlayson G, Blaak E, Gibbons C, Navas-Carretero S, Almiron-Roig E, Harrold J, Raben A, Martinez JA.
Publication name: Food & Function 2020 Dec 16. doi: 10.1039/d0fo02424d. Online ahead of print.
Publication year: 2020

Abstract Numerous strategies have been investigated to overcome the excessive weight gain that accompanies a chronic positive energy balance. Most approaches focus on a reduction…

Author(s): Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ
Publication name: Food Chem Toxicol. 2020 Apr 28:111375. doi: 10.1016/j.fct.2020.111375. [Epub ahead of print]
Publication year: 2020

Abstract The safety of low- and no-calorie sweeteners remains a topic of general interest. Substantial evidence exists demonstrating a lack of carcinogenicity of the no-calorie…

Author(s): Kim Y, Keogh JB, Clifton PM.
Publication name: Int. J. Environ. Res. Public Health 2020; 17(23): 9049; doi:10.3390/ijerph17239049 (open access).
Publication year: 2020

Abstract There is an association between the consumption of artificial sweeteners and Type 2 diabetes in cohort studies, but intervention studies do not show a…

Author(s): Rogers PJ, Ferriday D, Irani B, Hei Hoi JK, England CY, Bajwa KK and Gough T
Publication name: Appetite 2020 Feb 11; 149:104631. doi: 10.1016/j.appet.2020.104631. [Epub ahead of print]
Publication year: 2020

Abstract Sensory-specific satiety (SSS) describes a reduction in the pleasantness of the taste of (momentary liking) and desire to consume a food that occurs with…

Author(s): Martínez, X.; Zapata, Y.; Pinto, V.; Cornejo, C.; Elbers, M.; van der Graaf, M.; Villarroel, L.; Hodgson, M.I.; Rigotti, A.; Echeverría, G
Publication name: Nutrients 2020, 12(6), 1594; https://doi.org/10.3390/nu12061594
Publication year: 2020

Abstract After enforcement of a new food labeling law in 2016, Chile exhibits a greater offer to reduced sugar products with addition of non-nutritive sweeteners…

Author(s): Trumbo PR, Appleton KM, de Graaf K, Hayes JE, Baer DJ, Beauchamp GK, Dwyer JT, Fernstrom JD, Klurfeld DM, Mattes RD, Wise PM.
Publication name: Advances in Nutrition 2020 Dec 3; nmaa151. doi: 10.1093/advances/nmaa151.
Publication year: 2020

Abstract Various global public health agencies recommend minimizing exposure to sweet-tasting foods or beverages. The underlying rationale is that reducing exposure to the perception of…

Author(s): Lohner S, Kuellenberg de Gaudry D, Toews I, Ferenci T, Meerpohl JJ
Publication name: Cochrane Database of Systematic Reviews 2020 May 25;5:CD012885. doi: 10.1002/14651858.CD012885.pub2
Publication year: 2020

Abstract Background: Products sweetened with non-nutritive sweeteners (NNS) are widely available. Many people with type 1 or type 2 diabetes use NNS as a replacement…

Author(s): Greyling A, Appleton KM, Raben A, Mela DJ.
Publication name: American Journal of Clinical Nutrition 2020; 112(4);1002-1014. https://doi.org/10.1093/ajcn/nqaa167
Publication year: 2020

Abstract Background: It has been suggested that low-energy sweeteners (LES) may be associated with an increased risk of metabolic diseases, possibly due to stimulation of…

Author(s): David R. Tennant & Angeliki Vlachou
Publication name: Food Additives & Contaminants: Part A, DOI: 10.1080/19440049.2019.1619942
Publication year: 2019

Abstract Data on current use levels of E950 acesulfame K, E952 cyclamic acid and its Na and Ca salts, E954 saccharin and its Na, K…

Author(s): Ahmad SY, Friel JK, MacKay DS.
Publication name: Appl Physiol Nutr Metab. 2020 Jun;45(6):606-612. doi: 10.1139/apnm-2019-0359. Epub 2019 Nov 7.
Publication year: 2019

Abstract This study aimed to determine the effect of pure forms of sucralose and aspartame, in doses reflective of common consumption, on glucose metabolism. Healthy…

Author(s): Bueno-Hernández N, Vázquez-Frías R, Abreu y Abreu AT, Almeda-Valdés P, Barajas-Nava LA, Carmona-Sánchez RI, Chávez-Sáenz J, Consuelo-Sánchez A, Espinosa-Flores AJ, Hernández-Rosilesb V, Hernández-Vez G, Icaza-Chávez ME, Noble-Lugo A, A. Romo-Romo A
Publication name: Rev Gastroenterol Mex. 2019 Sep 26. pii: S0375-0906(19)30114-4. doi: 10.1016/j.rgmx.2019.08.001. [Epub ahead of print]
Publication year: 2019

Abstract The present review of noncaloric sweeteners (NCSs) by the Asociación Mexicana de Gastroenterología was carried out to analyze and answer some of the most frequent questions…

Author(s): Wikoff, D.S., Chappell, G.A., Fitch, S., Doepker, C.L., Borghoff, S.J
Publication name: Food and Chemical Toxicology 2020; 135 : 110866, 2020. 10.1016/j.fct.2019.110866
Publication year: 2019

Abstract Despite repeated confirmation of aspartame safety in a variety of foods and beverages, there continues to be interest in researching the potential carcinogenic risk…

Author(s): Chappell, G.A., Borghoff, S.J., Pham L, Doepker, C.L., Wikoff, D.S
Publication name: Food and Chemical Toxicology 2020; 135 : 110898. 10.1016/j.fct.2019.110898
Publication year: 2019

Abstract Sucralose is widely used as a sugar substitute. Many studies and authoritative reviews have concluded that sucralose is non-carcinogenic, based primarily on animal cancer…

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