Scientific library

The Science Library is a useful resource, which is easy to navigate, and provides abstracts and brief summaries with the main findings of key scientific studies published in peer-reviewed journals, on low/no calorie sweeteners’ safety, benefits and role in the diet.

Covering a wide range of topics such as the role of low/no calorie sweeteners in weight management and obesity, their use in diabetes management, their impact on oral health, their safety, the role of sweet taste overall, scientists and health professionals can easily find here all the latest studies of the scientific literature.

Author(s): Martyn D, Darch M, Floyd S, Ngo K, Fallah S
Publication name: Food Additives & Contaminants: Part A DOI: 10.1080/19440049.2021.2010812
Publication year: 2022

Abstract This research examined the intakes of six low- and no-calorie sweeteners (LNCS) (acesulfame-K, aspartame, cyclamate, saccharin, steviol glycosides, and sucralose) by the Brazilian population…

Author(s): McGlynn ND, Khan TA, Wang L, Zhang R, Chiavaroli L, Au-Yeung F, Lee J, Norohna JC, Comelli, EM, Mejia SB, Ahmed A, Malik VS, Hill JO, Leiter LA, Agarwal A, Jeppesen PB, Rahelić D, Kahleová H, Salas-Salvadó J, Kendall CC, Sievenpiper JL.
Publication name: JAMA Network Open 2022;5(3):e222092. doi:10.1001/jamanetworkopen.2022.2092
Publication year: 2022

Abstract IMPORTANCE There are concerns that low- and no-calorie sweetened beverages (LNCSBs) do not have established benefits, with major dietary guidelines recommending the use of…

Author(s): Carvalho C, Correia D, Severo M, Magalhãesa V, Casal S, Ramos E, Lopes C, Torres D
Publication name: Food Additives & Contaminants: Part A DOI: 10.1080/19440049.2022.2075039
Publication year: 2022

Abstract This study aimed to evaluate the risk of the Portuguese population’s exposure to six non-nutritive intense sweeteners (NNIS) and their main associated factors. A…

Author(s): Lee JJ, Khan TA, McGlynn N, Malik VS, Hill JO, Leiter LA, Jeppesen PB, Rahelić D, Kahleová H, Salas-Salvadó J, Kendall CWC, Sievenpiper JL.
Publication name: Diabetes Care. 2022 Aug 1;45(8):1917-1930. https://doi.org/10.2337/dc21-2130
Publication year: 2022

Abstract BACKGROUND Adverse associations of low- and no-calorie sweetened beverages (LNCSB) with cardiometabolic outcomes in observational studies may be explained by reverse causality and residual…

Author(s): Serrano J, Smith KR, Crouch AL, Sharma V, Yi F, Vargova V, LaMoia TE, Dupont LM, Serna V, Tang F, Gomes-Dias L, Blakeslee JJ, Hatzakis E, Peterson SN, Anderson M, Pratley RE, Kyriazis GA.
Publication name: Microbiome 2021;9:11. doi: 10.1186/s40168-020-00976-w
Publication year: 2021

Abstract Background: Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, some interventional studies in…

Author(s): Fitch SE, Payne LE, van de Ligt JLG, Doepker C, Handus D, Cohen SM, Anyangwe N, Wikoff D.
Publication name: BMC Public Health. 2021 May 20;21(1):956. doi: 10.1186/s12889-021-10934-2
Publication year: 2021

Abstract: Background It is well-recognized that consumers face many challenges in understanding and applying nutritional guidance for low-calorie sweeteners (LCS). Thus, this research aims to…

Author(s): Lee HY, Jack M, Poon T, Noori D, Venditti C, Hamamji S, Musa-Veloso K.
Publication name: Advances in Nutrition 2021 Jan 13;nmaa157. doi:10.1093/advances/nmaa157
Publication year: 2021

Abstract Effects of isocaloric (sweetness differences but constant calories) preloads and isosweet (caloric differences but constant sweetness) preloads, as well as preloads that were neither…

Author(s): Miranda, C.; Martinez, N.; Sotomayor, G.
Publication name: Chilean Food Safety and Quality Agency (ACHIPIA)
Publication year: 2021

Abstract: The Chilean Food Safety and Quality Agency (ACHIPIA) conducted a chronic dietary exposure assessment, requested by the Ministry of Health of Chile (MINSAL). Four…

Author(s): Farhat G, Dewison F, Stevenson L.
Publication name: Nutrients 2021; 13(2): 444. doi:10.3390/nu13020444
Publication year: 2021

Abstract Non-nutritive sweeteners (NNS) are popular sugar substitutes that can help in weight and diabetes management, but concerns regarding their use have been raised by…

Author(s): Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS.
Publication name: Food and Chemical Toxicology 2021;150:112045. doi: 10.1016/j.fct.2021.112045
Publication year: 2021

Abstract Steviol glycosides are present in the leaves of the Stevia rebaudiana plant, have a sweet taste, and have been used as a sweetener for centuries. To build on previous…

Author(s): Khan TA and Sievenpiper JL.
Publication name: Cell Metabolism 2021;33(2):P225-226.
Publication year: 2021

Abstract No abstract available Summary The Letter by Khan and Sievenpiper presents a re-analysis of data and discusses the findings of an earlier study by…

Author(s): Movahedian M, Golzan SA, Ashtary-Larky D, Clark CT, Asbaghi O & Hekmatdoost A.
Publication name: Crit Rev Food Sci Nutr 2021 Dec 9;1-17. https://doi.org/10.1080/10408398.2021.2012641
Publication year: 2021

Abstract: It has been posited that Non-nutritive sweeteners (NNS) intake may affect lipid profile. However, its proven effects on lipid profile are unclear, as clinical…

Author(s): Laviada-Molina H, Espinosa-Marrón A, Martinez-Portilla RJ, Molina-Segui F.
Publication name: Diabet Med. 2021 Jan 11:e14520. doi: 10.1111/dme.14520. Online ahead of print.
Publication year: 2021

Abstract There is a current debate on the effects of artificial sweeteners on health-related outcomes among different populations. Even when meta-analytic evidence has revealed that…

Author(s): Gallagher AM, Ashwell M, Halford JCG, Hardman CA, Maloney NG and Raben A.
Publication name: Journal on Nutritional Science 2021; 10:E7. doi:10.1017/jns.2020.59
Publication year: 2021

Abstract Overconsumption of free sugars, particularly from sugar-sweetened beverages (SSB), has potential negative health impacts. Implementation of a range of public health strategies is needed…

Author(s): Gujral J, Carr J, Tonucci D, Darwen C, Grotz VL.
Publication name: Toxicology Research and Application 2021;5:1–16. doi: 10.1177/23978473211019490 (open access)
Publication year: 2021

Abstract Regulatory agencies around the world have found sucralose to be a safe ingredient for use in food. A recent review by the German Federal…

Author(s): Normand M, Ritz C, Mela D, Raben A.
Publication name: BMJ Nutrition, Prevention & Health 2021; bmjnph-2020-000210. doi: 10.1136/bmjnph-2020-000210
Publication year: 2021

Abstract Objective Reviews on the relationship of low-energy sweeteners (LES) with body weight (BW) have reached widely differing conclusions. To assess possible citation bias, citation analysis…

Author(s): Barraj L, Bi X, Tran N
Publication name: Food Additives & Contaminants: Part A DOI: 10.1080/19440049.2021.1956692
Publication year: 2021

Abstract As obesity rates increase, several countries in Latin America have implemented strategies to curb the consumption of sugars, resulting in reformulations of products with…

Author(s): Laviada-Molina H, Molina-Segui F, Pérez-Gaxiola G, Cuello-García C, Arjona-Villicaña R, Espinosa-Marrón A, Martinez-Portilla RJ.
Publication name: Obesity Reviews 2020; 1-13. https://doi.org/10.1111/obr.13020
Publication year: 2020

Abstract There is an ongoing debate about the possible influences of nonnutritive sweeteners (NNS) on body weight. We conducted a systematic review and meta?analysis of…

Author(s): Ahmad SY, Friel JK, MacKay DS.
Publication name: Nutrients 2020; 12(11): 3408. Doi:10.3390/nu12113408
Publication year: 2020

Abstract Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine…

Author(s): Rogers PJ, Appleton KM.
Publication name: Int J Obes (2020). https://doi.org/10.1038/s41366-020-00704-2
Publication year: 2020

Abstract Previous meta-analyses of intervention studies have come to different conclusions about effects of consumption of low-calorie sweeteners (LCS) on body weight. The present review…

Author(s): Barraj L, Scrafford C, Bi X and Tran N.
Publication name: Food Additives & Contaminants: Part A, 2020. doi: 10.1080/19440049.2020.1846083
Publication year: 2020

Abstract Estimated intake of six low and no-calorie sweeteners (LNCS) (acesulfame potassium, aspartame, cyclamate, saccharin, steviol glycosides and sucralose) from processed foods and beverages, as…

Author(s): Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S and Small DM.
Publication name: Cell Metabolism 2020;31(3):493–502.
Publication year: 2020

Abstract There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes…

Author(s): Palatnik A, Moosreiner A, Olivier-Van Stichelen S.
Publication name: Am J Obstet Gynecol. 2020; 223(2): P211-P218
Publication year: 2020

Abstract In an effort to reduce sugar consumption to prevent diabetes mellitus and cardiovascular diseases, “sugar-free” or “no added sugar” products that substitute sugar with…

Author(s): Ashwell M, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, López-García R, Magnuson B, Mellor D, Rogers P, Rowland I, Russell W, Sievenpiper J, La Vecchia C
Publication name: Nutr Res Rev. 2020;33(1):145-154. doi: 10.1017/S0954422419000283. [Epub ahead of print]
Publication year: 2020

Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to…

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