Scientific library

The Science Library is a useful resource, which is easy to navigate, and provides abstracts and brief summaries with the main findings of key scientific studies published in peer-reviewed journals, on low/no calorie sweeteners’ safety, benefits and role in the diet.

Covering a wide range of topics such as the role of low/no calorie sweeteners in weight management and obesity, their use in diabetes management, their impact on oral health, their safety, the role of sweet taste overall, scientists and health professionals can easily find here all the latest studies of the scientific literature.

Author(s): Ashwell MA, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, López-García R, Magnuson B, Mellor D, Rogers P, Rowland I, Russell W, Sievenpiper J, La Vecchia C
Publication name: Nutr Res Rev. 2020;33(1):145-154. doi: 10.1017/S0954422419000283. [Epub ahead of print]
Publication year: 2020

Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to…

Author(s): Ashwell MA, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, López-García R, Magnuson B, Mellor D, Rogers P, Rowland I, Russell W, Sievenpiper J, La Vecchia C
Publication name: Nutr Res Rev. 2020;33(1):145-154. doi: 10.1017/S0954422419000283. [Epub ahead of print]
Publication year: 2020

Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to…

Author(s): Uriza RB, Méndez JAA, Cavagnari B, González CC, Tellez RC, Brambila JC, Marrón AE, Plascencia JL, López Alarcón MG, López García R, Maldonado Alvarado JdD, Molina Seguí F, Neri Ruz ES, Peralta Sánchez AE, Escamilla MTSR, Tena Alavez G, Riobó Serván P
Publication name: Nutr Hosp. 2020 Jan 21. doi: 10.20960/nh.02870. [Epub ahead of print] (article in Spanish)
Publication year: 2020

Abstract Non-nutritive sweeteners (NNS) are food additives that have been used as a possible tool to reduce energy and sugar intake. There is a scientific…

Author(s): Rogers PJ, Ferriday D, Irani B, Hei Hoi JK, England CY, Bajwa KK and Gough T
Publication name: Appetite 2020 Feb 11; 149:104631. doi: 10.1016/j.appet.2020.104631. [Epub ahead of print]
Publication year: 2020

Abstract Sensory-specific satiety (SSS) describes a reduction in the pleasantness of the taste of (momentary liking) and desire to consume a food that occurs with…

Author(s): Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ
Publication name: Food Chem Toxicol. 2020 Apr 28:111375. doi: 10.1016/j.fct.2020.111375. [Epub ahead of print]
Publication year: 2020

Abstract The safety of low- and no-calorie sweeteners remains a topic of general interest. Substantial evidence exists demonstrating a lack of carcinogenicity of the no-calorie…

Author(s): Ashwell MA, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, López-García R, Magnuson B, Mellor D, Rogers P, Rowland I, Russell W, Sievenpiper J, La Vecchia C
Publication name: Nutr Res Rev. 2020;33(1):145-154. doi: 10.1017/S0954422419000283. [Epub ahead of print]
Publication year: 2020

Abstract A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to…

Author(s): Martínez, X.; Zapata, Y.; Pinto, V.; Cornejo, C.; Elbers, M.; van der Graaf, M.; Villarroel, L.; Hodgson, M.I.; Rigotti, A.; Echeverría, G
Publication name: Nutrients 2020, 12(6), 1594; https://doi.org/10.3390/nu12061594
Publication year: 2020

Abstract After enforcement of a new food labeling law in 2016, Chile exhibits a greater offer to reduced sugar products with addition of non-nutritive sweeteners…

Author(s): Lohner S, Kuellenberg de Gaudry D, Toews I, Ferenci T, Meerpohl JJ
Publication name: Cochrane Database of Systematic Reviews 2020 May 25;5:CD012885. doi: 10.1002/14651858.CD012885.pub2
Publication year: 2020

Abstract Background: Products sweetened with non-nutritive sweeteners (NNS) are widely available. Many people with type 1 or type 2 diabetes use NNS as a replacement…

Author(s): Greyling A, Appleton KM, Raben A, Mela DJ.
Publication name: American Journal of Clinical Nutrition 2020; 112(4);1002-1014. https://doi.org/10.1093/ajcn/nqaa167
Publication year: 2020

Abstract Background: It has been suggested that low-energy sweeteners (LES) may be associated with an increased risk of metabolic diseases, possibly due to stimulation of…

Author(s): Laviada-Molina H, Molina-Segui F, Pérez-Gaxiola G, Cuello-García C, Arjona-Villicaña R, Espinosa-Marrón A, Martinez-Portilla RJ.
Publication name: Obesity Reviews 2020; 1-13. https://doi.org/10.1111/obr.13020
Publication year: 2020

Abstract There is an ongoing debate about the possible influences of nonnutritive sweeteners (NNS) on body weight. We conducted a systematic review and meta?analysis of…

Author(s): Ahmad SY, Friel JK, MacKay DS.
Publication name: Nutrients 2020; 12(11): 3408. Doi:10.3390/nu12113408
Publication year: 2020

Abstract Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine…

Author(s): Rogers PJ, Appleton KM.
Publication name: Int J Obes (2020). https://doi.org/10.1038/s41366-020-00704-2
Publication year: 2020

Abstract Previous meta-analyses of intervention studies have come to different conclusions about effects of consumption of low-calorie sweeteners (LCS) on body weight. The present review…

Author(s): Carissa M. Baker-Smith, Sarah D. de Ferranti, William J. Cochran and COMMITTEE ON NUTRITION, SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION
Publication name: Pediatrics. 2019;144(5):e20192765
Publication year: 2019

Abstract The prevalence of nonnutritive sweeteners (NNSs) in the food supply has increased over time. Not only are more children and adolescents consuming NNSs, but…

Author(s): Mariscal-Ramírez LA, Alberú-Gómez JM, Amato-Martínez JD, Bochicchio-Ricardelli T, Campos-González ID, Cervera-Saldaña VR, Chew-Wong A, Espinosa-Marrón A, Medeiro-Domingo M, Molina-Segui F, Muñoz-Arizpe R, Laviada-Molina H
Publication name: Nefro Latinoam. 2019;16:46-57 (article in Spanish)
Publication year: 2019

Abstract Non-caloric sweeteners (NCS) are food additives with sweet taste used as a tool to substitute sugar consumption and reduce energy intake. There is scientific…

Author(s): Morahan HL, Leenaars C.H.C, Boakes R.A., Rooney K.B
Publication name: Physiol Behav. 2019 Oct 21:112696
Publication year: 2019

Abstract Little is known about possible effects of maternal non-nutritive sweetener (NNS) consumption on the metabolic health of a child. Animal models of maternal NNS…

Author(s): Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, Mitri J, Pereira RF, Rawlings K, Robinson S, Saslow L, Uelmen A, Urbanski PB, Yancy Jr. WS
Publication name: Diabetes Care. 2019 May;42(5):731-754
Publication year: 2019

Summary This Consensus Report of the American Diabetes Association (ADA) is intended to provide clinical professionals with evidence-based guidance about individualizing nutrition therapy for adults…

Author(s): David R. Tennant
Publication name: Food Additives & Contaminants: Part A, DOI: 10.1080/19440049.2019.1566784
Publication year: 2019

Abstract Reliable estimation of intake of non-nutritive sweeteners (NNS) from tabletop sweetener products (TTS) is complex. Some TTS contain more than one type of NNS…

Author(s): Haighton L, Roberts A, Jonaitis T, Lynch B
Publication name: Regulatory Toxicology and Pharmacology 2019; 103: 352-362
Publication year: 2019

Abstract Given the widespread use of the low-calorie sweetener aspartame over the last 30 years, the current work was undertaken to evaluate aspartame epidemiology studies…

Author(s): Thomson P, Santibañez R, Aguirre C, Galgani JE, Garrido D.
Publication name: British Journal of Nutrition 2019;122(8):856-862. doi:10.1017/S0007114519001570
Publication year: 2019

Abstract Sucralose is an artificial non-nutritive sweetener used in foods aimed to reduce sugar and energy intake. While thought to be inert, the impact of…

Author(s): David R. Tennant & Angeliki Vlachou
Publication name: Food Additives & Contaminants: Part A, DOI: 10.1080/19440049.2019.1619942
Publication year: 2019

Abstract Data on current use levels of E950 acesulfame K, E952 cyclamic acid and its Na and Ca salts, E954 saccharin and its Na, K…

Author(s): Ahmad SY, Friel JK, MacKay DS.
Publication name: Appl Physiol Nutr Metab. 2020 Jun;45(6):606-612. doi: 10.1139/apnm-2019-0359. Epub 2019 Nov 7.
Publication year: 2019

Abstract This study aimed to determine the effect of pure forms of sucralose and aspartame, in doses reflective of common consumption, on glucose metabolism. Healthy…

Author(s): Bueno-Hernández N, Vázquez-Frías R, Abreu y Abreu AT, Almeda-Valdés P, Barajas-Nava LA, Carmona-Sánchez RI, Chávez-Sáenz J, Consuelo-Sánchez A, Espinosa-Flores AJ, Hernández-Rosilesb V, Hernández-Vez G, Icaza-Chávez ME, Noble-Lugo A, A. Romo-Romo A
Publication name: Rev Gastroenterol Mex. 2019 Sep 26. pii: S0375-0906(19)30114-4. doi: 10.1016/j.rgmx.2019.08.001. [Epub ahead of print]
Publication year: 2019

Abstract The present review of noncaloric sweeteners (NCSs) by the Asociación Mexicana de Gastroenterología was carried out to analyze and answer some of the most frequent questions…

Author(s): Toews I, Lohner S, Kullenberg de Gaudry D, Sommer H, Meerpohl JJ
Publication name: BMJ 2019; 364: k4718
Publication year: 2019

Abstract Objective: To assess the association between intake of non-sugar sweeteners (NSS) and important health outcomes in generally healthy or overweight/obese adults and children. Design:…

Author(s): Wikoff, D.S., Chappell, G.A., Fitch, S., Doepker, C.L., Borghoff, S.J
Publication name: Food and Chemical Toxicology 2020; 135 : 110866, 2020. 10.1016/j.fct.2019.110866
Publication year: 2019

Abstract Despite repeated confirmation of aspartame safety in a variety of foods and beverages, there continues to be interest in researching the potential carcinogenic risk…

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