Low-energy sweeteners and body weight: a citation network analysis.
Abstract Objective Reviews on the relationship of low-energy sweeteners (LES) with body weight (BW) have reached widely differing conclusions. To assess possible citation bias, citation analysis was used to quantify the relevant characteristics of cited articles, and explore citation patterns in relation to review conclusions. Design A systematic search identified reviews published from January 2010 to March […]
Use of sucralose in foods heated during manufacturing does not pose a risk to human health
Abstract Regulatory agencies around the world have found sucralose to be a safe ingredient for use in food. A recent review by the German Federal Institute for Risk Assessment (BfR) hypothesized that sucralose use in foods heated during their manufacture might pose a health risk, by resulting in the formation of certain chlorinated compounds; specifically, […]
Letter to the editors regarding the article “Consumption of non-nutritive sweeteners in pregnancy”
Abstract This is a letter from the International Sweeteners Association in response to an article by Palatnik et al regarding the effects of the consumption of nonnutritive sweeteners (NNSs) during pregnancy on maternal and child health. The authors claim that emerging evidence from animal studies warns against the consumption of NNSs. This assertion is not supported […]
Consumption of non-nutritive sweeteners in pregnancy
Abstract In an effort to reduce sugar consumption to prevent diabetes mellitus and cardiovascular diseases, “sugar-free” or “no added sugar” products that substitute sugar with non-nutritive sweeteners (NNSs) (eg, Splenda, Sweet’N Low, and Stevia) have become increasingly popular. The use of these products during pregnancy has also increased, with approximately 30% of pregnant women reporting […]
Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.
Abstract There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but […]
Low-Calorie Sweeteners with Carbohydrate Do Not Impair Insulin Sensitivity in Humans: Re-analysis Highlighting the Importance of the Comparator.
Abstract No abstract available Summary The Letter by Khan and Sievenpiper presents a re-analysis of data and discusses the findings of an earlier study by Dalenberg et al (2020), rejecting the assertion that the consumption of sucralose in the presence of a carbohydrate impairs glucose metabolism. Dalenberg et al supported in their study that the […]
Lack of potential carcinogenicity for steviol glycosides – Systematic evaluation and integration of mechanistic data into the totality of evidence
Abstract Steviol glycosides are present in the leaves of the Stevia rebaudiana plant, have a sweet taste, and have been used as a sweetener for centuries. To build on previous authoritative safety assessments of steviol glycosides, a systematic assessment of mechanistic data related to key characteristics of carcinogens (KCCs) was conducted. Over 900 KCC-relevant endpoints from peer-reviewed literature and high-throughput […]
Knowledge and Perceptions of Non Nutritive Sweeteners Within the UK Adult Population
Abstract Non-nutritive sweeteners (NNS) are popular sugar substitutes that can help in weight and diabetes management, but concerns regarding their use have been raised by the public. This study aimed to investigate knowledge, benefits and safety perceptions of NNS in a sample of UK adults. The impact of knowledge dissemination on the change in perceptions […]
Effects of Unsweetened Preloads and Preloads Sweetened with Caloric or Low-/No-Calorie Sweeteners on Subsequent Energy Intakes: A Systematic Review and Meta-Analysis of Controlled Human Intervention Studies
Abstract Effects of isocaloric (sweetness differences but constant calories) preloads and isosweet (caloric differences but constant sweetness) preloads, as well as preloads that were neither isosweet nor isocaloric (sweetness and caloric differences) on subsequent ad libitum meal and total (preload + ad libitum) energy intakes were investigated. Thirty-five crossover studies were eligible for inclusion, representing […]
High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice
Abstract Background: Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, some interventional studies in humans and rodents have shown unfavorable changes in glucose homeostasis in response to NCAS consumption. The causative mechanisms are largely unknown, but adverse changes in gut microbiota have been proposed […]