Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota
Abstract Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes […]
Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)
Abstract Purpose: Observational studies have demonstrated increased colon cancer recurrence and mortality in states of excess energy balance, as denoted by factors including sedentary lifestyle, diabetes, increased dietary glycemic load, and increased intake of sugar-sweetened beverages. Nonetheless, the relation between artificially sweetened beverages, a popular alternative for sugar-sweetened beverages, and colon cancer recurrence and survival is […]
Low-/No-Calorie Sweeteners: A Review of Global Intakes
Abstract The current review examined published data on the intake of all major low-/no-calorie sweeteners – aspartame, acesulfame-K, saccharin, sucralose, cyclamate, thaumatin and steviol glycosides – globally over the last decade. The most detailed and complex exposure assessments were conducted in Europe, following a standardized approach. Japan and Korea similarly had up-to-date and regular intake […]
Systematic review and evaluation of aspartame carcinogenicity bioassays using quality criteria
Abstract The current review assessed cancer studies of aspartame based on a quality appraisal using the Klimisch grading system. Nine studies having complete histopathology were included: three 2-year studies by Searle; three transgenic mice studies by the NTP; three lifetime studies by the Ramazzini Institute. A tenth study limited to brain tumors was not rated. […]
Dietary intakes of six intense sweeteners by Irish adults
Abstract This research investigated the intakes of six intense sweeteners; acesulfame-K (E950), aspartame (E951), cyclamate (E952), saccharin (E954), sucralose (E955) and steviol glycosides (E960) in the diets of Irish adults, using data from the National Adult Nutrition Survey (NANS). A food label survey which included products currently available on the Irish market supplemented the analysis. […]
Low calorie sweeteners in childhood: analysis of the scientific evidence (Edulcorantes no calóricos en la edad pediátrica: análisis de la evidencia científica)
Abstract Artificial sweeteners are food additives with the technological function of conferring a sweet taste on foods, but with a very low or zero nutritional energy value. There are doubts among consumers about the health risks that might be associated with the use of non-caloric sweeteners. In the pediatric community, there is interest in the […]
Aspartame: A review of genotoxicity data
Abstract Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to […]
Non-nutritive Sweeteners for Diabetes Mellitus
Abstract Background: Products sweetened with non-nutritive sweeteners (NNS) are widely available. Many people with type 1 or type 2 diabetes use NNS as a replacement for nutritive sweeteners to control their carbohydrate and energy intake. Health outcomes associated with NNS use in diabetes are unknown. Objectives: To assess the effects of non-nutritive sweeteners in people […]
Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report
Summary This Consensus Report of the American Diabetes Association (ADA) is intended to provide clinical professionals with evidence-based guidance about individualizing nutrition therapy for adults with diabetes or prediabetes. Nutrition counselling that works toward improving or maintaining glycaemic targets, achieving weight management goals, and improving cardiovascular risk factors (e.g., blood pressure, lipids, etc.) within individualized […]
Consensus of the Latin-American Association of Diabetes on low calorie sweeteners in persons with diabetes
Abstract While non-caloric sweeteners (NCS) are food additives that have been used as a tool to reduce sugar consumption and total energy intake, there is currently a scientific debate around the real benefits of its use. NCS are some of the most evaluated substances in the scientific literature. Their security has been reviewed by international […]