Prolonged Effects of Sweeteners and Sweetness Enhancers on Postprandial Appetite Sensations, Palatability, and Ad Libitum Energy Intake in Humans: A SWEET Sub-Study
Abstract Background/Objectives: Sweeteners and sweetness enhancers (S&SEs) have been proposed to potentially impair appetite regulation by stimulating sweet taste receptors beyond the perception of sweetness, similar to caloric sweeteners. The evidence is, however, not clear. Methods: This sub-study investigated the acute effects of a mixture of acesulfame potassium and cyclamate (Ace-K/Cyc) versus water on postprandial appetite […]
Artificially Sweetened Beverages and Weight Change: Findings from Three Prospective Cohort Studies of U.S. Adults
Abstract Background: Whether habitually consuming artificially sweetened beverages (ASBs) in place of sugar-sweetened beverages (SSBs) is associated with weight changes is unclear. Objectives: To evaluate the association of increasing ASBs or water, as SSBs replacements, with changes in weight/body mass index (BMI). Methods: We analyzed data from the Nurses’ Health Study (NHS), NHS II, and […]
Association between artificial sweeteners and cancer risk: an umbrella meta-analyses study
Abstract Background: Artificial sweeteners (AS) are widely used as sugar substitutes, particularly among individuals with metabolic disorders. Although AS are approved by regulatory authorities, concerns regarding their potential association with cancer risk persist due to inconsistent findings across studies. This umbrella review aimed to comprehensively synthesize evidence from published meta-analyses evaluating the association between AS […]
Health Effects of Sugar-Sweetened and Artificially Sweetened Beverages: Umbrella Review and Evidence-Based Consensus Statement of the Korean Diabetes Association and the Korean Nutrition Society
Abstract Background: Excess intake of added sugars contributes to obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and premature mortality. Sugar-sweetened beverages (SSBs), the main source of added sugars, are consistently linked to adverse outcomes. Artificially sweetened beverages (ASBs) have been suggested as short-term substitutes, but evidence regarding benefits and harms remains inconclusive, and […]
The Effect of Substituting Water for Artificially Sweetened Beverages on Glycemic and Weight Measures in People With Type 2 Diabetes: The Study of Drinks With Artificial Sweeteners (SODAS), a Randomized Trial
Abstract Objective: To test the effect of substituting plain water (the ideal standard) for habitual artificial sweetened beverage (ASB) intake by people with type 2 diabetes (T2D) on primary measures of diabetes control. Research design and methods: The Study of Drinks with Artificial Sweeteners in People with T2D (SODAS) was conducted at two academic health centers and […]
Reconciling conflicting evidence on low- and no-calorie sweeteners and cardiometabolic outcomes: an umbrella review using naïve and bias-adjusted methods
Abstract Inconsistency among evidence syntheses has led to opposing guidelines and public confusion regarding low- and no-calorie sweeteners (LNCS) in noncommunicable diseases. To understand the role of different analytical approaches in assessing LNCS and cardiometabolic outcomes, we conducted an umbrella review of systematic reviews and meta-analyses. MEDLINE, EMBASE, and Cochrane were searched for systematic reviews […]
Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study
Abstract Consumption of sweeteners and sweetness enhancers (S&SEs) is a popular strategy to reduce sugar intake, but the role of S&SEs in body weight regulation and gut microbiota composition remains debated. Here, we show that S&SEs in a healthy diet support weight loss maintenance and beneficial gut microbiota shifts in adults with overweight or obesity. […]
Re-evaluation of neotame (E 961) as food additive
Abstract The present opinion deals with the re-evaluation of neotame (E 961) as a food additive. Neotame is the chemically manufactured compound N-[N-(3,3-dimethylbutyl)-l-α-aspartyl]-l-phenylalanine 1-methyl ester. The main impurity of neotame (E 961) is also a degradation product (de-esterified form), N-[N-(3,3-dimethylbutyl)-l-α-aspartyl]-l-phenylalanine (NC-00751) and the primary metabolite. No new data were received following the call for biological […]
Three independent measures of sweet taste liking have weak and inconsistent associations with sugar and sweet food intake – insights from the sweet tooth study
Abstract Authoritative public health agencies, like the WHO, recommend reducing dietary sweetness to lower sweet liking, and thereby indirectly lowering sugar and energy intake. However, data on an association between sweetness liking and sugar/sweet food intake are inconsistent. Moreover, sweetness liking can be measured in various ways, and the agreement between methods is unclear. Baseline […]
Re-evaluation of acesulfame K (E 950) as food additive
Abstract The present opinion deals with the re-evaluation of acesulfame K (E 950) as a food additive. Acesulfame K (E 950) is the chemically manufactured compound 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide potassium salt. It is authorised for use in the European Union (EU) in accordance with Regulation (EC) No 1333/2008. The assessment involved a comprehensive review of existing authorisations, […]