In the context of the 3rd ISA Conference in November 2018 in London, the ISA interviewed Prof Carlo La Vecchia, Professor of Medical Statistics and Epidemiology at the University of Milan, Italy, about low calorie sweeteners and chronic diseases. In his interview, Prof La Vecchia tells us more about what the evidence shows about low calorie sweeteners and cancer risk and about the outcomes of his recent study on low calorie beverage consumption, diet quality and cardiometabolic risk factors.