Safety

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Critical Review of the Current Literature on the Safety of Sucralose

Author(s): Magnuson BA, Roberts A, Nestmann ER
Publication Name: Food and Chemical Toxicology, 2017 May 27. pii: S0278-6915(17)30281-8. doi: 10.1016/j.fct.2017.05.047. [Epub ahead of print]
Publication Year: 2017

Having reviewed the extensive database of studies on sucralose safety, this thorough review of the literature by Magnuson et al., concludes that the collective evidence supports a clear demonstration of safety of use of sucralose as a non-caloric swe...

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Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute

Author(s): EFSA, Panel on Food Additives and Nutrient Sources Added to Food
Publication Name: EFSA Journal 2017;15(5):4784
Publication Year: 2017

The European Food Safety Authority (EFSA) rejected the findings of another questionable study by the Ramazzini Institute and, as expected, reaffirmed sucralose safety, concluding that the available data did not support the conclusions of the authors ...

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Sugar- and artificially-sweetened beverages and the risks of incident stroke and dementia: A prospective cohort study

Author(s): Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF
Publication Name: Stroke, 2017 May; 48(5): 1139-1146. doi: 10.1161/STROKEAHA.116.016027.
Publication Year: 2017

Using prospective data from the Framingham Offspring Cohort, the findings in Pase et al. cannot provide evidence or a plausible mechanism for a causal link between diet drinks’ consumption and stroke and dementia. Importantly, the suggested associati...

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Assessment of dietary intake of 10 intense sweeteners by the Italian population.

Author(s): Donne CL, Mistura L, Goscinny S, Janvier S, Cuypers K, D'Addezio L, Sette S, Catasta G, Ferrari M, Piccinelli R, Van Loco J, Turrini A.
Publication Name: Food and Chemical Toxicology, 2017; 102: 186e197
Publication Year: 2017

Having collected and analysed a representative sample of 326 foods containing low calorie sweeteners, and upon estimation of the dietary exposure using the tiered approach, the study by Le Donne et al concludes that there is no risk related to the co...

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Biological fate of low-calorie sweeteners

Author(s): Magnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG
Publication Name: Nutrition Reviews 2016 Nov; 74(11): 670-689.
Publication Year: 2016

This review provides in depth information on the absorption, distribution, metabolism and excretion of the five commonly used LCS: Ace-K, aspartame, saccharin, sucralose and steviol glycosides, as well as an overview of the scientific literature show...

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Sucralose non-carcinogenicity: A review of the scientific and regulatory rationale

Author(s): Colin Berry, David Brusick, Samuel M. Cohen, Jerry F. Hardisty, V. Lee Grotz & Gary M. Williams
Publication Name: Nutrition and Cancer 2016; DOI: 10.1080/01635581.2016.1224366
Publication Year: 2016

This comprehensive systematic review examined all the available evidence and studies testing the safety and carcinogenicity of sucralose and confirmed that the sweetener is safe to consume and does not cause cancer. Sucralose does not demonstrate car...

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