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Diabetes Care

J Am Diet Assoc. 2003 Dec; 103(12): 1607-12
Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes
Grotz VL, Henry RR, McGill JB, Prince MJ, Shamoon H, Trout JR, Pi-Sunyer FX
This double-blind randomised study investigated the effect of high doses of sucralose on blood sugar levels in people with type 2 diabetes. 128 obese people with type 2 diabetes completed the study, and were split into a placebo group or a sucralose group. The study demonstrated that sucralose consumption for 3 months at 7.5mg/kg/day had no effect on blood sugar levels in people with type 2 diabetes.
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Am J Ther. 2003 Nov-Dec;10(6):438-43
Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients
Reyna NY, Cano C, Bermúdez VJ, Medina MT, Souki AJ, Ambard M, Nuñez M, Ferrer MA, Inglett GE
The introduction of fat and sugar replacers has led to a revolutionary advance in treating obesity and diabetes. This study compares the improvements in overall health and weight from a diet based on the American Diabetic Association's nutrition recommendations with a modified low-energy diet including a fat replacer and low calorie sweeteners. The study concluded that a diet incorporating a fat replacer and low calorie sweeteners led to a greater improvement in overall health and weight.
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Ernährungsumschau, 1993; 40(4): 152-155
The influence of sweetener solutions on the secretion of insulin and the blood glucose level
Härtel B, Graubaum H-J and Schneider B
This study determined whether low calorie sweeteners (aspartame, acesulfame-k, cyclamate and saccharin) would affect the secretion of insulin, which could lead to changes in the blood sugar levels. The study demonstrated that there was no difference in blood sugar levels of people who had consumed a low calorie beverage and those who had consumed water.
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Diabetes Care. 1988 Mar;11(3):230-4
Response to single dose of aspartame or saccharin by NIDDM patients
Horwitz DL, McLane M, Kobe P
10 people with non-insulin dependent diabetes (NIDDM) and 12 normal people were given, in random order at intervals of more than a week, three versions of the same beverage: one unsweetened, one sweetened with aspartame and one sweetened with saccharin. The study showed that the ingestion of beverages sweetened with aspartame or saccharin by people with or without diabetes did not affect blood sugar levels.
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Diabetes Res Clin Pract. 1986 Apr;2(1):23-7
Glucose tolerance, blood lipid, insulin and glucagon concentration after single or continuous administration of aspartame in diabetics
Okuno G, Kawakami F, Tako H, Kashihara T, Shibamoto S, Yamazaki T, Yamamoto K, Saeki M
Aspartame was given to diabetic people and normal people in order to see if there was any effect on blood sugar levels. No increase in blood sugar levels was found, rather a small decrease in blood sugar levels was noticed. The second study determined the effect of 2 weeks continuous administration of aspartame, equal in sweetness to the daily consumption of sugar, to 9 diabetics. There was no significant change in blood sugar levels. These studies concluded that aspartame can be a useful alternative sweetener for people with diabetics.
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